A comparison of autologous serum, plasma, and whole blood for intradermal autoreactivity testing in patients with chronic spontaneous urticarial: A cross-sectional study

Background: Autologous serum (ASST) and plasma (APST) skin testing confirm autoreactivity in chronic spontaneous urticaria (CSU). Whole blood autohemotherapy has been used. Plasma even whole may be used instead of with relatively quicker preparation cheaper method especially using the latter centers limited resources. Purpose: The purpose study is to determine if similar intradermal reactions can observed when either serum, plasma, or autologous tests factors associated positive wheal diameter. Methods: We performed a cross-sectional patients dermatology clinic. Tests were according EAACI/GA2 LEN Task Force recommendations. Urticaria Activity Score over 7 days (UAS7) was assessed. Statistical analyses included Chi-square, Mann–Whitney U, Spearman's, Wilcoxon rank tests. Results: Twenty-six (77%) females 8 (24%) males mean age 34 (26–42) years participated. ASST, APST for (AWBST) positivity rates 24%, 29% 27%, respectively (P = 0.86). 13 (38%) had at least 1 test; all negative 21 (62%). All (21%), 3 (23%) alone, 2 (15%) AWBST, (8%) ASST. Pretest UAS7 higher those test 0.04). Test results unaffected by age, gender, disease duration, atopy, anti-nuclear antibody, thyroid status. Wheal diameter correlated thyroid-stimulating hormone Conclusion: Autoreactivity APST, AWBST. Positive severe CSU. simpler less costly alternative urticaria.